[A Case of Mixed Connective Tissue Disease Positive for Proteinase 3 Antineutrophil Cytoplasmic Antibody in a Patient with Slowly Progressive Type 1 Diabetes Mellitus and Chronic Thyroiditis].
Nihon Rinshō Men'eki Gakkai kaishi/Nihon Rinshou Men'eki Gakkai kaishi(2017)
摘要
A female in her sixties with slowly progressive type 1 diabetes mellitus (SPT1DM) and chronic thyroiditis was referred to our rheumatology department with swelling in her fingers. A prominent atherosclerotic lesion was revealed upon brain magnetic resonance imaging, and she was found to have mixed connective tissue disease (MCTD) positive for proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA). This rare case of MCTD accompanying SPT1DM and PR3-ANCA suggested that a synergy between MCTD and PR3-ANCA triggers atherosclerosis.
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