Baseline and Serial Brain Natriuretic Peptide Level Predicts 5-Year Overall Survival in Patients With Pulmonary Arterial Hypertension: Data From the REVEAL Registry.

Baseline BNP threshold of 340 pg/mL strongly predicted survival up to 5-years in patients with PAH. A BNP reduction at 1 year since enrollment was associated with decreased mortality risk, while an increase in BNP at 1 year was associated with an increased mortality risk, supporting BNP as a surrogate marker of PAH survival.