3D Structure Determination of a Protein in Living Cells Using Paramagnetic NMR Spectroscopy
Chemical Communications(2016)
摘要
Determining the three-dimensional structure of a protein in living cells remains particularly challenging. We demonstrated that the integration of site-specific tagging proteins and GPS-Rosetta calculations provides a fast and effective way of determining the structures of proteins in living cells, and in principle the interactions and dynamics of protein-ligand complexes.
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关键词
Protein Structure Determination,NMR Spectroscopy
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