LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1α.

Wei Zhang,Weitang Yuan,Junmin Song,Shijun Wang,Xiaoming Gu

Biochimie（2018）

引用 80|浏览15

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摘要

•Hypoxia might induce autophagy in CRC.•LncRNA CPS1-IT suppresses metastasis and EMT by inhibiting hypoxia-induced autophagy through inactivation of HIF-1α in CRC.•The role of lncRNA CPS1-IT1 on autophagy and EMT under hypoxia.

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关键词

CPS1 intronic transcript 1 (CPS1-IT1),Colorectal carcinoma (CRC),Hypoxia-inducible factor-1 alpha (HIF-1α),Epithelial-mesenchymal transition (EMT),Autophagy

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