Genetic Diversity of Leishmania Donovani That Causes Cutaneous Leishmaniasis in Sri Lanka: a Cross Sectional Study with Regional Comparisons

Udeshika Lakmini Kariyawasam,Angamuthu Selvapandiyan,Keshav Rai, Tasaduq Hussain Wani,Kavita Ahuja, Mizra Adil Beg, Hasitha Upendra Premathilake,Narayan Raj Bhattarai,Yamuna Deepani Siriwardena,Daibin Zhong,Guofa Zhou,Suman Rijal,Hira Nakhasi,Nadira D. Karunaweera

BMC infectious diseases（2017）

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摘要

Leishmania donovani is the etiological agent of visceral leishmaniasis (VL) in the Indian subcontinent. However, it is also known to cause cutaneous leishmaniasis (CL) in Sri Lanka. Sri Lankan L. donovani differs from other L. donovani strains, both at the molecular and biochemical level. To investigate the different species or strain-specific differences of L. donovani in Sri Lanka we evaluated sequence variation of the kinetoplastid DNA (kDNA).

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关键词

Skin lesions,Antimony resistance,Visceral leishmaniasis,kDNA minicircle sequences,Haplotype diversity,Geographical clustering,Phenotypic characteristics,Nepal,India

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