Rapid Diagnosis of Tuberculosis from Analysis of Urine Volatile Organic Compounds
ACS sensors(2016)
Abstract
The World Health Organization has called for simple, sensitive, and nonsputum diagnostics for tuberculosis. We report development of a urine tuberculosis test using a colorimetric sensor array (CSA). The sensor comprising 73 different indicators captures high-dimensional, spatiotemporal signatures of volatile chemicals emitted by human urine samples. The sensor responses to 63 urine samples collected from 22 tuberculosis cases and 41 symptomatic controls were measured under 5 different urine test conditions. Basified testing condition yielded the best accuracy with 85.5% sensitivity and 79.5% specificity. The CSA urine assay offers desired features needed for tuberculosis diagnosis in endemic settings.
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Key words
colorimetric sensor array,electronic nose,chemical sensor,urine headspace,tuberculosis
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