Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimer’s disease pathophysiology

Francisca Cornejo, Marianne Vruwink,Claudia Metz,Paola Muñoz,Nicole Salgado, Joaquín Poblete,María Estela Andrés,Jaime Eugenín,Rommy von Bernhardi

Brain, Behavior, and Immunity（2018）

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摘要

•SR-A in hippocampus is reduced by aging and Aβ accumulation.•APP/PS1/SR-A−/− mice activation changes leading to the neuroinflammation and Aβ accumulation.•APP/PS1/SR-A−/− mice show cognitive impairment earlier than APP/PS1 mice.

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关键词

Aging,Beta-amyloid plaques,Glial cells,Neurodegenerative diseases,Neuroinflammation,Scavenger receptor

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