Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. Jun Liang , Anne Van Abbema , Mercedesz Balazs , Kathy Barrett , Leo Berezhkovsky , Wade S Blair , Christine Chang , Donnie Delarosa , Jason DeVoss , Jim Driscoll , Charles Eigenbrot , Simon Goodacre , Nico Ghilardi , Calum MacLeod , Adam Johnson , Pawan Bir Kohli , Yingjie Lai , Zhonghua Lin , Priscilla Mantik , Kapil Menghrajani , Hieu Nguyen , Ivan Peng , Amy Sambrone , Steven Shia , Jan Smith , Sue Sohn , Vickie Tsui , Mark Ultsch , Karen Williams , Lawren C Wu , Wenqian Yang , Birong Zhang , Steven Magnuson Bioorganic & Medicinal Chemistry Letters（2017）
关键词
TYK2, Kinase, Psoriasis, Imidazopyridine, IL-23
AI 理解论文
溯源树
样例
