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Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.

Shuzhi Dong,Kelsey VanGelder,Zhi-Cai Shi,Yang Yu,Zhicai Wu,Ron Ferguson,Zack Zhiqiang Guo,Haifeng Tang,Jessica Frie,Qinghong Fu,Xin Gu,Birgit T Priest,Brande Thomas-Fowlkes,Adam Weinglass,Michael Margulis,Jessica Liu,Lee-Yuh Pai,Caryn Hampton,Robin E Haimbach,Karen Owens,Vincent Tong,Shiyao Xu,Mengwei Hu,Gloria J Zingaro,Pierre Morissette,Juliann Ehrhart,Sophie Roy,Kathleen Sullivan,Alexander Pasternak

Bioorganic & Medicinal Chemistry Letters（2017）

Cited 8|Views35
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Key words
hERG,ROMK,Hypertension,Heart failure,Diuresis,Natriuresis,Spirocycle
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