N Terminal N-methylation Modulates Chiral Centre Induced Helical (CIH) Peptides’ Biophysical Properties

The effects of N-methylation on CIH peptides' biophysical properties were systematically studied. N-Methylation at the N terminal NH could help improve the peptides' cellular uptake with a retained helical conformation. This N-methylation strategy could also be applied to longer peptides to improve their stability and cellular uptake.