Definite Stent Thrombosis after Drug-Eluting Stent Implantation in Coronary Bifurcation Lesions: A Meta-Analysis of 3,107 Patients from 14 Randomized Trials
Catheterization and cardiovascular interventions(2017)
摘要
Background Bifurcation percutaneous coronary intervention (PCI) is a challenging procedure, but there are currently inadequate data about definite stent thrombosis (ST) rates of single-stent versus double-stent strategies (SS and DS, respectively). Methods and resultsConclusionsRandomized clinical trials (RCTs) comparing SS and DS strategies were searched through PubMed, Embase, and the Cochrane Central Register of Controlled Trials. Fourteen RCTs involving 3,107 patients were analyzed. Owing to the high crossover rate (16.49%), both intention-to-treat (ITT) and as-treated (AT) analyses were performed. In the ITT population, there was a significantly lower rate of early definite ST in the SS group (0.26%; DS group 1.14%; P=0.021). Similarly, in the AT population, there was a significantly lower rate of early definite ST in the SS group (0.23%, DS group 1.07%; P=0.042). True bifurcation subgroup analysis also showed a significantly lower early definite ST in the SS group (OR=0.36, 95% CI=0.15-0.86, P=0.042) in the ITT population. There was no significant difference of overall, acute, subacute, and late definite ST between the 2 groups. Early definite ST is reduced when a SS strategy is used in bifurcation lesions.
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关键词
bifurcation,drug-eluting stents,percutaneous coronary intervention,stent thrombosis
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