A dipolar cycloaddition reaction to access 6-methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines enables the discovery synthesis and preclinical profiling of a P2X7 antagonist clinical candidate.
JOURNAL OF MEDICINAL CHEMISTRY（2018）
Key words
dipolar cycloaddition reaction,antagonist,discovery synthesis
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