Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8 + T Cells During Relapse after Allogeneic Stem Cell Transplantation.

Tim J A Hutten,Wieger J Norde,Rob Woestenenk, Ruo Chen Wang,Frans Maas,Michel Kester,J H Frederik Falkenburg,Sofia Berglund,Leo Luznik,Joop H Jansen,Nicolaas Schaap,Harry Dolstra,Willemijn Hobo

Biology of Blood and Marrow Transplantation（2018）

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摘要

•PD-1, TIGIT, and TIM-3 are highly (co)expressed on MiHA-specific CD8+ T cells.•MiHA-specific CD8+ T cells exhibit an early differentiation phenotype.•Relapsed patients' MiHA-specific CD8+ T cells show increased (co)expression of PD-1, TIGIT, and KLRG-1 compared to nonrelapsed patients.

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关键词

MiHA,Allo-SCT,PD-1,TIGIT and T cells

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