CMOS-nano-bio interface array for cardiac and neuro technology

Summary form only given. Optical methods based on voltage sensitive proteins and Ca2+/voltage sensitive dyes have significantly benefited the field of electrophysiology, parallelizing intracellular recording from a network of electrogenic cells. Creating an analogous all-electrical device - an electrode array capable of intracellular recording from a network of electrogenic cells - has long been an outstanding challenge. On the one hand, though the CMOS microelectrode array has enabled network-level studies with massive parallelism, its extracellular interface has a limited sensitivity. On the other hand, planar patch clamp arrays achieve intracellular access but are not applicable to network-level interrogations. We will present our recent development of a CMOS nanoelectrode array that combines both parallel and intracellular features for high-precision recording across a large network of electrogenic cells, and its outlooks in neurobiology and cardiology.