Heparan Sulfate Inhibits Inflammation and Improves Wound Healing by Downregulating the NLR Family Pyrin Domain Containing 3 (NLRP3) Inflammasome in Diabetic Rats

Heparan sulfate (HS) attenuates the inflammatory response and improves diabetic wound healing in rats. However, the specific mechanisms by which HS suppresses inflammation are not clear. Given that NLR family pyrin domain containing 3 (NLRP3) is a major receptor involved in innate immune regulation, the aim of the present study was to elucidate the effects of HS on NLRP3 and proinflammatory cytokines in diabetic wounds.