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Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function

Marika Markkanen, Anastasia Ludwig,Stanislav Khirug,Evgeny Pryazhnikov,Shetal Soni,Leonard Khiroug,Eric Delpire,Claudio Rivera,Matti S. Airaksinen,Pavel Uvarov

Brain Research（2017）

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Abstract
•KCC2a isoform is expressed at the neuronal plasma membrane.•KCC2a isoform mediates chloride extrusion in cultured neurons.•SPAK differently regulates kinetic activity of KCC2a and KCC2b isoforms.
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Key words
GABA,SPAK,HA-SPAK,OSR1,DNSPAK
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