CART neuropeptide modulates the extended amygdalar CeA-vBNST circuit to gate expression of innate fear.

Abhishek Rale,Ninad Shendye,Devika S Bodas,Nishikant Subhedar,Aurnab Ghose

Psychoneuroendocrinology（2017）

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摘要

•The CeA mediates TMT-induced innate fear responses.•vBNST neurons are downstream targets of CeA activation by TMT.•CART peptidergic activity in the CeA modulates vBNST activation and response to TMT.•CART activity modulates NMDA-R signaling in CeA neurons.•Gating of the CeA-vBNST axis activity by CART is central to innate fear processing.

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关键词

Innate fear,Fear circuitry,TMT,CART neuropeptide,Amygdala,BNST

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