Semi-automatic Synthesis and Biodistribution of N-(2-18F-fluoropropionyl)-bis(zinc (Ii)-Dipicolylamine) (18F-Fp-dpazn2) for AD Model Imaging

Fuhua Wen,Dahong Nie,Kongzhen Hu,Ganghua Tang,Shaobo Yao,Caihua Tang

BMC medical imaging（2017）

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摘要

Phosphatidylserine (PS)-targeting positron emission tomography (PET) imaging with labeled small-molecule tracer is a crucial non-invasive molecule imaging method of apoptosis. In this study, semi-automatic radiosynthesis and biodistribution of N-(2-18F-fluoropropionyl)-bis(zinc(II)-dipicolylamine) (18F-FP-DPAZn2), as a potential small-molecule tracer for PET imaging of cell death in Alzheimer’s disease (AD) model, were performed.

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关键词

18F-NFP,18F-FP-DPAZn2,Semi-automatic synthesis,Zinc(II)-dipicolylamine,Cell death

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