SOCS-1 is involved in TNF-α-induced mitochondrial dysfunction and apoptosis in renal tubular epithelial cells.

•TNF-α induced expression of SOCS-1.•Overexpression of SOCS-1 inhibited mitochondrial dysfunction, oxidative stress and apoptosis induced by TNF-α.•Overexpression of SOCS-1 inhibited activation of JAK/STAT signaling pathway induced by TNF-α.