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Macrocyclic Inhibitors of Factor XIa: Discovery of Alkyl-Substituted Macrocyclic Amide Linkers with Improved Potency

James R. Corte,Wu Yang,Tianan Fang,Yufeng Wang,Honey Osuna,Amy Lai,William R. Ewing, Karen A. Rossi,Joseph E. Myers,Steven Sheriff,Zhen Lou,Joanna J. Zheng,Timothy W. Harper,Jeffrey M. Bozarth,Yiming Wu,Joseph M. Luettgen,Dietmar A. Seiffert,Mimi L. Quan,Ruth R. Wexler,Patrick Y. S. Lam

Bioorganic & medicinal chemistry letters（2017）

Cited 16|Views40
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Key words
Factor Xla inhibitors,FXla,Activated partial thromboplastin time,aPTT,Thrombosis
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