A Multi-Centre, Non-Inferiority, Randomised Controlled Trial to Compare a Cervical Pessary with a Cervical Cerclage in the Prevention of Preterm Delivery in Women with Short Cervical Length and a History of Preterm Birth – PC Study

Preterm birth is in quantity and in severity the most important contributor of perinatal morbidity and mortality both in well- and low-resource countries. Cervical pessary and cervical cerclage are both considered as preventive treatments in women at risk for preterm birth. We aim to evaluate whether a cervical pessary can replace cervical cerclage for preventing recurrent preterm birth in women with a prior preterm birth due to cervical insufficiency or in women with a prior preterm birth and a short cervix in the current pregnancy.