PM2.5 Upregulates the Expression of MUC5AC via the EGFR-PI3K Pathway in Human Sinonasal Epithelial Cells.

Jian Jiao,Puqi Hu,Ying Li,Chao Cai,Xiangdong Wang,Luo Zhang

International archives of allergy and immunology（2022）

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摘要

This study demonstrates that short-term PM2.5 exposure increases MUC5AC expression in HNECs. Furthermore, this study shows that PM2.5-induced MUC5AC expression is likely mediated through the EGFR-PI3K pathway.

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关键词

Epidermal growth factor receptor,Fine particulate matter,Human nasal epithelial cells,Mucin 5AC,Phosphoinositide 3-kinase

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