DNA Methylation Mediates the Effect of Exposure to Prenatal Maternal Stress on Cytokine Production in Children at Age 13½ Years: Project Ice Storm

Lei Cao-Lei,Franz Veru,Guillaume Elgbeili,Moshe Szyf,David P. Laplante,Suzanne King

Clinical Epigenetics（2016）

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摘要

Prenatal maternal stress (PNMS) is an important programming factor of postnatal immunity. We tested here the hypothesis that DNA methylation of genes in the NF-κB signaling pathway in T cells mediates the effect of objective PNMS on Th1 and Th2 cytokine production in blood from 13½ year olds who were exposed in utero to the 1998 Quebec ice storm.

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关键词

Prenatal maternal stress,DNA methylation,Mediation effect,Cytokines,NF-κB signaling,IFN-γ

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