ELF5 and DOK7 Regulation in Anti-Estrogen Treated Cells and Tumors
Cancer Cell International(2016)
摘要
Most women with primary breast cancers that express estrogen receptor alpha (ER or ESR1) are treated with endocrine therapies including the anti-estrogen tamoxifen, but resistance to these anti-endocrine therapies often develops. This study characterizes the expression of hormone receptors, and the mRNA and DNA methylation levels of docking protein 7 (DOK7), and E74-like factor 5 (ELF5), in 21 novel tamoxifen-resistant cell lines and extends the findings to primary and recurrent human breast tumors.
更多查看译文
关键词
Breast cancer,DOK7,ELF5,Estrogen receptor,Progesterone receptor,Tamoxifen resistance
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要