Synthesis and Antifungal Activity of 3-Substituted Imidazo[1,2-B][1,2,4,5]tetrazines

R. I. Ishmetova,N. K. Ignatenko, I. A. Belyaninova,S. G. Tolshchina,A. V. Korotina,P. A. Slepukhin,N. P. Evstigneeva,N. V. Zil’berberg, P. G. Amineva,N. V. Kungurov,G. L. Rusinov,O. N. Chupakhin

Russian chemical bulletin（2015）

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摘要

A number of new 3-substituted imidazo[1,2-b][1,2,4,5]tetrazines containing azolyl, aminopyridyl, and alkoxyl substituents was synthesized. These compounds were studied for the biological activity against mycelial anthropophilic and zoophilous dermatophyte fungi (Trichophyton, Microsporum and Epidermophyton), causing diseases of skin and its appendages (hair, nails), and yeast-like fungi Candida.

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关键词

1,2,4,5-tetrazines,imidazo[1,2-b][1,2,4,5]tetrazines,antifungal activity,nucleophilic substitution

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