Neutralization of EP217609, a New Dual-Action FIIa/FXa Anticoagulant, by Its Specific Antidote Avidin: a Phase I Study

P. Gueret,S. Combe,C. Krezel,E. Fuseau,P. L. M. van Giersbergen,M. Petitou,E. Neuhart

European journal of clinical pharmacology（2016）

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摘要

EP217609 is a representative of a new class of synthetic parenteral anticoagulants with a dual mechanism of action. It combines in a single molecule a direct thrombin inhibitor and an indirect factor Xa inhibitor. EP217609 can be neutralized by a specific antidote avidin, which binds to the biotin moiety of EP217609.

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关键词

EP217609,Avidin,Dual thrombin and indirect Xa inhibition,Reversal,Pharmacokinetics and pharmacodynamics,Healthy subjects

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