Interleukin-6 Receptor-Alpha Signaling Drives Anti-Rbc Alloantibody Production and T-follicular Helper Cell Differentiation in a Murine Model of Red Blood Cell Alloimmunization

Despite the significant clinical consequences of red blood cell (RBC) alloimmunization, our understanding of the fundamental molecular and cellular mechanisms regulating anti-RBC antibody generation is limited. Relative to infectious stimuli,[1][1] transfused RBCs induce a less robust antibody