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A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.

Margaret A. Phillips,Karen L. White,Sreekanth Kokkonda,Xiaoyi Deng,John White,Farah El Mazouni,Kennan Marsh,Diana R. Tomchick,Krishne Manjalanagara, Kakali Rani Rudra,Grennady Wirjanata,Rintis Noviyanti,Ric N. Price,Jutta Marfurt,David M. Shackleford,Francis C. K. Chiu,Michael Campbell,Maria Belen Jimenez-Diaz,Santiago Ferrer Bazaga,Inigo Angulo-Barturen,Maria Santos Martinez,Maria Lafuente-Monasterio,Werner Kaminsky,Kigbafori Silue,Anne-Marie Zeeman,Clemens Kocken,Didier Leroy,Benjamin Blasco,Emilie Rossignol,Thomas Rueckle,Dave Matthews,Jeremy N. Burrows,Michael J. Palmer,Pradipsinh K. Rathod,Susan A. Charman

ACS Infectious Diseases（2016）

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关键词
malaria,Plasmodium,pyrirnidine biosynthesis,dihydroorotate dehydrogenase
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