Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

NATURE CHEMICAL BIOLOGY（2016）

引用 163|浏览43

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摘要

The application of a potent lactate dehydrogenase (LDHA) inhibitor GNE-140 on pancreatic cancer cells revealed that resistance to GNE-140 is attributable to an AMPK–mTOR–S6K-mediated switch in utilization from glycolysis to oxidative phosphorylation.

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关键词

Small molecules,Cancer therapy,Metabolic pathways,Cell signalling

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