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Arginase-1 is Expressed Exclusively by Infiltrating Myeloid Cells in CNS Injury and Disease.

Andrew D Greenhalgh,Rosmarini Passos Dos Santos,Juan Guillermo Zarruk,Christopher K Salmon,Antje Kroner,Samuel David

Brain, Behavior, and Immunity（2016）

Cited 51|Views23
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Abstract
•Arginase-1 is expressed exclusively in infiltrating myeloid cells and not microglia in SCI and EAE.•LysM-EGFP mouse is a good model to distinguish between infiltrating myeloid cells and microglia in CNS injury and disease.•Factors in the CNS environment prevent Arginase-1 expression in microglia during inflammation.
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Key words
Arginase-1,Microglia,Macrophages,Inflammation,CNS injury,LysM-EGFP
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