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Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf Inhibitors: Applying Mutant Versus Wild-Type B-Raf Selectivity Indices for Compound Profiling

Longbin Liu,Matthew R. Lee,Joseph L. Kim,Douglas A. Whittington,Howard Bregman,Zihao Hua,Richard T. Lewis,Matthew W. Martin,Nobuko Nishimura,Michele Potashman,Kevin Yang,Shuyan Yi,Karina R. Vaida,Linda F. Epstein,Carol Babij,Manory Fernando,Josette Carnahan,Mark H. Norman

Bioorganic & Medicinal Chemistry（2016）

引用 3|浏览67
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关键词
B-Raf,Inhibitor,DFG,C-helix,Selectivity,v600e,Wild-type,Sulfonamide
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