Chemoselective and Sequential Palladium-Catalyzed Couplings for the Generation of Stilbene Libraries Via Immobilized Substrates

A versatile palladium-catalyzed tandem synthetic sequence to afford E-stilbenes libraries has been developed. Excellent regio- and stereocontrol have been achieved by means of the sequence of Hiyama and Heck cross-couplings. Undesirable homocoupling byproducts were avoided employing immobilized substrates.