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Characterization of surface antigen protein 1 (SurA1) from Acinetobacter baumannii and its role in virulence and fitness.

Dong Liu,Zeng-Shan Liu,Pan Hu, Ling Cai,Bao-Quan Fu,Yan-Song Li,Shi-Ying Lu,Nan-Nan Liu,Xiao-Long Ma,Dan Chi,Jiang Chang,Yi-Ming Shui,Zhao-Hui Li,Waqas Ahmad,Yu Zhou,Hong-Lin Ren

Veterinary Microbiology（2016）

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Abstract
•The surface antigen protein 1 (SurA1) gene of A. baumannii was identified, cloned and expressed.•The cytotoxic effect of recombinant SurA1 was tested on two cell lines.•SurA1 knock-out strain exhibited a lower killing activity in Galleria mellonella.•SurA1 knock-out strain showed obvious defect on fitness and growth.
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Key words
Acinetobacter baumannii,Surface antigen protein 1,Gene replacement,Galleria mellonella,Virulence,Fitness
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