O-Arylation of Iodophenols with 2-Fluorobenzaldehyde under Microwave Conditions
Letters in drug design & discovery(2013)
摘要
The arylation of 4-iodo-, 2-iodo- and 3-iodophenols with 2-fluorobenzaldehyde may be carried out in the presence of K2CO3 in DMF as the solvent under microwave conditions. The arylation of 4-iodophenole was promoted by the use of triethylbenzylammonium chloride (TEBAC) as the phase transfer catalyst. In the other model reactions, the use of TEBAC was harmful. By-products formed by isomerization and disproportionation were also detected.
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关键词
2-Flourobenzaldehyde,Iodophenols,Arylation,Microwave,Phase transfer catalysis
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