Remote detection of the surface-enhanced Raman spectrum with the optical fiber nanoprobe

Optical fiber nanoprobe with gold nanoparticles substrate on the surface was prepared by electrostatic self-assembly technology. Surface-enhanced Raman spectrum of the cells was measured using the optical fiber nanoprobe by remote detection method and direct detection method using confocal Raman micro-spectroscopy. The spectrum were analyzed with the detailed chemical components. The remote detection method using the optical fiber nanoprobe could make the probe inserting into the cells or tissue, and that may be helpful for the online SERS measurement of the cells in the biomedical research and diagnosis in the future.