Toll-like Receptor 2 Polymorphism in Juvenile Dermatomyositis

Background Juvenile dermatomyositis (JDM) is characterised by chronic inflammation in skeletal muscle, skin, and other target organs. Prognosis has improved in the past 10-20 years, but it is still a disease with high morbidity and considerable sequelae such as muscle weakness, joint contractures, calcinosis and lipodystrophy. There is increasing evidence that single nucleotide polymorphisms (SNPs) are associated with chronic inflammatory diseases. In the present study, we investigated known SNPs within genes that previously have been associated with inflammatory myopathies, including JDM and dermatomyositis.