Beneficial Effect of 3-Hydroxytyrosol on Chondrocytes Exposed to Oxidative Stress

Purpose: A major opportunity is represented by the search for food-derived molecules able to interfere with the processes involved in the pathogenesis or progression of chronic degenerative- and age-related diseases, such as osteoarthritis (OA). Recent findings attributed a potential role to autophagy in the regulation of the cellular response to several stress stimuli. Although its role is context- and tissue-dependent and still unclear, autophagy has been observed to decrease during aging and several age-related diseases, including OA.