Chemical constituents of the leaves from Rollinia leptopetala R. E. Fries

CHEMICAL CONSTITUENTS OF THE LEAVES FROM Rollinia leptopetala R. E. FRIES. The phytochemical investigation of Rollinia leptopetala led to the isolation of a new compound named a-terpinyl caffeate, and five known compounds, being three sesquiterpenes, spathulenol. beta-caryophyllene and 4 beta,10 alpha-aromadendrane-diol, and two alkaloids, (-)-3-hydroxynornuciferine and (+)-norisocorydine. These alkaloids are being described for the first time in this genus. The structures of the compounds were determined by analysis of IR. MS and NMR data, as well as by comparison with literature data. The crude extract of R. leptopetala leaves demonstrated a weak cytotoxicity on sarcoma 180 cells with an IC50 of 512.3 mu g/mL. However, the in vivo results showed that the extract exhibited a significant dose-dependent tumor growth reduction.