Relationship Status, Sexual Orientation and Reproductive Outcomes in Recipients of Both Egg and Sperm Donations

pick-up (OPU) protocol. We analyzed 12,483 donation cycles, 74 of which EFS. These cycles were compared to a matched cohort from the donor population; 64 EFS and non-EFS cycles in the same donor were also compared. All EFS cycles were triggered with either βhCG or GnRHa. Multivariate analysis and logistic regression were employed. EFS incidence was 0.59%. There were no differences in gonadotropic stimulation, hypophysary suppression and triggering; this was confirmed when comparing EFS and non-EFS cycles in the same donors. More days of stimulation were needed to reach triggering criteria (10.9 vs. 10.1, p=0.004) in EFS cycles compared to control despite the initial dose of stimulation being the same. In 15 cases triggered with GnRHa, a second trigger and OPU were carried out; rescue triggers with GnRHa did not recover any oocytes (0/2 cases), while βhCG rescue obtained oocytes in 85% (11/13) of cases; ET was performed in 87% of them, resulting in a pregnancy rate of 28.5%. A temporary hypothalamic–hypophysary hyposensitivity can explain the cases where a rescue protocol with βhCG has been successful, suggesting a possible etiology for EFS.