A Driver or a Passenger? D421-caspase Cleaved Tau is Associated with Aggregated and Insoluble Tau

between four and eight months of age and importantly caspase-cleaved tau was shown to be associated with the insoluble fraction of tau. These changes are concomitant with progression of tau pathological changes previously observed in this model. Conclusions Caspase-cleaved tau at D421 is associated with aggregated and insoluble tau. Our findings contribute to the discussion on whether therapeutics aimed at inhibiting caspase-mediated tau cleavage could be beneficial in slowing cleavage and aggregation, and hence potentially inhibit the pathological cascade in Alzheimer’s disease.