Sa1945 The Effect of Acute and Chronic Stress on Rabbit Esophageal Epithelium

duodenal epithelial cells accompanied by increased blood flow and MGT.L-798106 reduced the effects of PGE 2 , whereas L-161982 inhibited MGT increase alone.Sulprostone mimics the effects of PGE 2 on pH i , blood flow and MGT, whereas TCS2510 increased pH i and MGT without hyperemia.These results suggest that PGE 2 -induced mucus secretion is mediated via EP3 and EP4 receptors, accompanied by DBS and intracellular alkalinization, consistent with the necessity of HCO 3 -for mucin release.Unlike DBS, which can be stimulated independently by EP3 and EP4 receptors, mucus secretion, consisting of exocytosis, migration and exfoliation, may require cooperative activation of EP3 and EP4 receptors.