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Distributions of TEC Fluctuations and Losses of Lock Associated with Equatorial Plasma Bubbles

mag(2009)

Cited 23|Views7
Key words
indexation,electron density,total electron content,space weather,spatial scale,wave propagation,ionosphere,earth observation
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要点】:研究通过生物标志物分析确认了干燥综合征(Sjögren's Disease, SjD)三种不同表型的独特病理生理途径,并发现高干扰素签名与系统性发展风险增加相关。

方法】:利用系统体征与干燥综合征演变评估队列(Assessment of Systemic Signs and Evolution in Sjögren's Syndrome cohort)的20年前瞻性数据,比较了IFN-alpha 2、IFN-gamma等九种生物标志物,并通过转录组分析评估了干扰素签名。

实验】:共纳入395名患者,通过比较三种表型(B细胞活跃低症状型[BALS]、高系统性活动型[HSA]、低系统性活动高症状型[LSAHS])的生物标志物表达,发现BALS和HSA集群中CXCL13、IL-7和TNF-RII水平较高,而高干扰素签名主要出现在BALS集群中,并与新的免疫抑制剂治疗风险增加相关。所有淋巴瘤均发生在高干扰素签名患者中。