A Novel HDAC Inhibitor AB3 Reduces Cell Proliferation and Induces the Notch Pathway in Medullary Thyroid Cancer Cells

S. Tesfazghi,A. Harrison,A. Dammalapati,C. Korlesky,C.M. Schienebeck,W. Tang,R. Jaskula-Sztul,H. Chen

The Journal of surgical research/Journal of surgical research（2014）

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摘要

Medullary thyroid cancer (MTC) is a rare and aggressive neuroendocrine (NE) tumor with limited treatment options. Surgery is not curative, with patients having recurrent and/or incurable disease. AB3 is a novel HDAC inhibitor which shows promise as a potential therapeutic. Its effects of decreasing cell proliferation, NE tumor markers, and activation of the Notch pathway in MTC cell lines (TT and MZ) were investigated for the first time.

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