Modulation of ROS Production in Photodynamic Therapy Using a Ph Controlled Photoinduced Electron Transfer (PET) Based Sensitiser.

A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.