In Vivo Retinal Imaging Using Liquid Crystal Adaptive Optics with Different Color Illumination

We have developed a high-resolution, multi-color retinal imaging system using liquid crystal adaptive optics. A liquid crystal on silicon (LCOS) spatial light modulator (SLM) is used to correct ocular aberrations. In order to compensate for the dependency of an LCOS SLM on optical wavelength and acquire aberration-corrected images at different color, we apply an open-loop technique. In the open-loop technique, the imaging light is separated from the sensing light and the optimal phase modulation is applied only to the imaging light while the sensing light is not phase-modulated. With the system, in vivo imaging of the human retina is achieved by using illumination light at wavelength of 655nm and 593nm and sensing light at 780nm. Photoreceptors are clearly revealed at each illumination wavelength with the liquid crystal adaptive optics.