Functions of dendritic-cell-bound IgE in allergy

•Constitutive expression of trimeric FcɛRI on DCs modulates the serum and the cell-bound IgE pool at steady state and during allergy.•DC-bound IgE does not lead to a spontaneous allergic phenotype.•FcɛRI on DCs contributes to IgE clearance, which is considered anti-inflammatory.•Antigen-specific crosslinking of IgE/FcɛRI on DCs induces immune regulatory responses that diminish tissue allergy in vivo.