Resveratrol and curcumin ameliorate di-(2-ethylhexyl) phthalate induced testicular injury in rats

Amal Ahmed Abd Elfattah,Atef Tadros Fahim,Nermin Abdel Hamid Sadik,Bassam Mohamed Ali

General and Comparative Endocrinology（2016）

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摘要

•Di-(2-ethylhexyl) phthalate (DEHP) caused an oxidative testicular damage in rats.•Resveratrol or curcumin attenuated the DEHP-induced pathological alterations.•The effects of these compounds may be due to their intrinsic antioxidant properties.•These compounds boosted Nrf2/HO-1, HSP60, HSP70 and HSP90 gene expression levels.

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关键词

ACP,ALP,AR,ARE,CMC,DEHP,FSH,FRAP,GSH,HO-1,HSE,HSP,HSF-1,LH,LDH,MDA,MEHP,Nrf2,PVC,RT-PCR,ROS,SIRT1,TSSKs,TPTZ,TAC

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