The LEXSY platform for recombinant protein expression

Due to the increasing demand for production of recombinant proteins in the proteomics era and the shortcomings of the traditional protein expression systems we have developed the LEXSY expression platform based on the protozoan organism Leishmania tarentolae. This unicellular eukaryotic host is safe (biosafety group S1), robust, easy and cost-efficient to culture and has the full capacity for eukaryotic protein folding and modification including mammalian-type post-translational glycosylation. We demonstrated an exceptionally homogeneous biantennary structure of fully galactosylated, core-α-1,6-fucosylated N-glycans of LEXSY expressed glycoproteins (Figure 1).