Silver-Catalyzed Cross-Coupling Reaction of Propargylic Alcohols and Arylisocyanides: an Atom-Economic Synthesis of N-Aryl-2,3-Allenamides

A silver-catalyzed cross-coupling of propargylic alcohols and aryl isocyanides to N-aryl-2,3-allenamides has been developed. This reaction is both atom and step economic and applicable to a broad scope of substrates, affording a range of synthetically useful N-aryl-2,3-allenamides in good to high yields under mild conditions. This protocol has successfully solved the problem in our previous report that the isocyanides were limited to active methylene isocyanides, provided an extremely simple way to access the synthetically useful N-aryl-2,3-allenamides.