Hypoxia Alters Syncytiotrophoblastic Microparticles (Stbm)-Related Coagulation Capacities

Introduction: Endothelial dysfunction, defined as vasoconstiction and platelet activation, is thought to be the cause of preeclampsia (PE) symptoms. Especially severe forms of the pregnancy-associated pathology PE is correlated to the release of syncytiotrophoblastic microparticles (STBM), which triggers inflammatory processes on the endothelium. The thrombogenic potential of STBMs, however, are not well characterized.